In 1991, Warren G formed the group 213 with Nate Dogg and Snoop Dogg. Warren G introduced the group to his step-brother Dr. Dre. Dr. Dre was impressed and tied Snoop Dogg and Nate Dogg to his and Suge Knight’s record company, Death Row Records. Thus, 213 broke up before releasing any records, and the three artists pursued separate careers. Even though Death Row Records did not sign Warren G, his career began with some contributions to Dr. Dre’s album The Chronic, released 1992.

Warren G’s debut album Regulate... G Funk Era was released in 1994 and featured the hit "Regulate" sampling Michael McDonald’s classic hit , "I Keep Forgettin’". Also on that disc was "This DJ," a popular track and hit video on MTV.

He followed up with "Take a Look Over Your Shoulder (Reality)" in 1997, which took his mellow approach and brought it even further into pop. While scoring a mild hit with a rap remake of "I Shot the Sheriff," the album was a commercial disappointment and was criticized among fans for its repetitiveness and limited pop sensibility.

"I Want It All," released in 1999, represented a substantive if not commercial comeback for Warren G. Widely regarded as his most consistent record, this offered a jazz-rock fusion style and a host of guests including Mack 10, Snoop Dogg, Kurupt, and Eve. The first single, "I Want It All," sampled an LL Cool J beat had a hit video that entered into heavy rotation on MTV and VH1. Warren G fully embraced his less-gangsta image at this time.

The greatest disappointment of Warren G’s career was undoubtedly "The Return of the Regulator," the full-out comeback album he released in 2001 after signing with Universal Records. Using similar cover art to his original successful album, "Regulate... G Funk Era," Warren G tried to recreate his 1994 magic to no avail. The album was a major sales disappointment and produced no hit singles. However, the album was actually an artistic high point for Warren G. Several of the songs, including "Something for You to Bounce To" and "Young Locs Slow Down," are classics in his catalogue.

In 2003 Warren G, Snoop Dogg and Nate Dogg reunited 213 and recorded the album The Hard Way with the single "Groupie Luv". The album was released in 2004 and entered at #4 on the Billboard Charts.